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2021

Unit Publication
Oswal A
Cao C
Yeh CH
Neumann WJ
Gratwicke J
Akram H
Horn A
Li D
Zhan S
Zhang C
Wang Q
Zrinzo L
Foltynie T
Limousin P
Bogacz R
Sun B
Husain M
Brown P
Litvak V

Neural signatures of hyperdirect pathway activity in Parkinson's disease.

2021. Nat. Commun., 12(1):5185.
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PMC8408177
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4.09 MB
Unit Publication
Khawaldeh S
Tinkhauser G
Torrecillos F
He S
Foltynie T
Limousin P
Zrinzo L
Oswal A
Quinn AJ
Vidaurre D
Tan H
Litvak V
Kühn AA
Woolrich M
Brown P

Balance between competing spectral states in subthalamic nucleus is linked to motor impairment in Parkinson's disease.

2021. Brain : in press.
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5.39 MB
Unit Publication
Huang Y
Sun B
Debarros J
Zhang C
Zhan S
Li D
Zhang C
Wang T
Huang P
Lai Y
Brown P
Cao C
Tan H

Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients.

2021. eLife, 10:e65444.
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PMC8275130
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3.64 MB
Unit Publication
Duchet B
Ghezzi F
Weerasinghe G
Tinkhauser G
Kühn AA
Brown P
Bick C
Bogacz R

Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease.

2021. PLoS Comput. Biol., 17(7):e1009116.
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PMC8263069
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3.91 MB
Unit Publication
Oswal A
Gratwicke J
Akram H
Jahanshahi M
Zaborszky L
Brown P
Hariz M
Zrinzo L
Foltynie T
Litvak V

Cortical connectivity of the nucleus basalis of Meynert in Parkinson's disease and Lewy body dementias.

2021. Brain, 144(3):781-788.
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PMC8041337
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646.53 KB
Unit Publication
He S
Baig F
Mostofi A
Pogosyan A
Debarros J
Green AL
Aziz TZ
Pereira EA
Brown P
Tan H

Closed-Loop Deep Brain Stimulation for Essential Tremor Based on Thalamic Local Field Potentials.

2021. Mov. Disord., 36(4):863-873.
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PMC7610625
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1.41 MB
Unit Publication
Wiest C
Tinkhauser G
Pogosyan A
He S
Baig F
Morgante F
Mostofi A
Pereira EA
Tan H
Brown P
Torrecillos F

Subthalamic deep brain stimulation induces finely-tuned gamma oscillations in the absence of levodopa.

2021. Neurobiol. Dis., 152:105287.
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PMC7116781
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10.76 MB

2020

Unit Publication
Debarros J
Brown P
Tan H
Denison T

Patent: Emulation of electrophysiological signals derived by stimulation of a body

2020. WO 2020/165591
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4.48 MB
Unit Publication
Muthuraman M
Bange M
Koirala N
Ciolac D
Pintea B
Glaser M
Tinkhauser G
Brown P
Deuschl G
Groppa S

Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson's disease.

2020. Brain, 143(11):3393-3407.
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PMC7116448
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1.09 MB
Unit Publication
He S
Mostofi A
Syed EC
Torrecillos F
Tinkhauser G
Fischer P
Pogosyan A
Hasegawa H
Li Y
Ashkan K
Pereira EA
Brown P
Tan H

Subthalamic beta-targeted neurofeedback speeds up movement initiation but increases tremor in Parkinsonian patients.

2020. eLife, 9:e60979.
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PMC7695453
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1.9 MB
Unit Publication
Baaske MK
Kormann E
Holt AB
Gulberti A
McNamara CG
Pötter-Nerger M
Westphal M
Engel AK
Hamel W
Brown P
Moll CK
Sharott A

Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo.

2020. Neurobiol. Dis., 146:105119.
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PMC7710979
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7.35 MB
Unit Publication
Fischer P
He S
de Roquemaurel A
Akram H
Foltynie T
Limousin P
Zrinzo L
Hyam J
Cagnan H
Brown P
Tan H

Entraining stepping movements of Parkinson's patients to alternating subthalamic nucleus deep brain stimulation.

2020. J. Neurosci., 40(46):8964–8972.
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PMC7659462
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1017.91 KB
Unit Publication
Piña-Fuentes D
van Dijk JMC
van Zijl JC
Moes HR
van Laar T
Oterdoom DLM
Little S
Brown P
Beudel M

Acute effects of adaptive Deep Brain Stimulation in Parkinson's disease.

2020. Brain Stimul., 13(6):1507-1516.
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PMC7116216
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808.1 KB
Unit Publication
Wang HL
Cheng W
Rolls ET
Dai F
Gong W
Du J
Zhang WN
Wang S
Liu F
Wang J
Brown P
Feng J

Association of specific biotypes in patients with Parkinson disease and disease progression.

2020. Neurology, 95(11):e1445-e1460.
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PMC7116258
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1.73 MB
Unit Publication
Shah SA
Brown P
Gimeno H
Lin JP
McClelland VM

Application of Machine Learning Using Decision Trees for Prognosis of Deep Brain Stimulation of Globus Pallidus Internus for Children With Dystonia.

2020. Front. Neurol., 11:825.
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PMC7115974
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1.43 MB
Unit Publication
Wiest C
Tinkhauser G
Pogosyan A
Bange M
Muthuraman M
Groppa S
Baig F
Mostofi A
Pereira EA
Tan H
Brown P
Torrecillos F

Local field potential activity dynamics in response to deep brain stimulation of the subthalamic nucleus in Parkinson's disease.

2020. Neurobiol. Dis., 143:105019.
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PMC7115855
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4.15 MB
Unit Publication
Yeh CH
Al-Fatly B
Kühn AA
Meidahl AC
Tinkhauser G
Tan H
Brown P

Waveform changes with the evolution of beta bursts in the human subthalamic nucleus.

2020. Clin. Neurophysiol., 131(9):2086-2099.
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PMC7115847
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1.62 MB
Unit Publication
Debarros J
Brown P
Tan H

Patent: Measurement of electrophysiological signals during stimulation of a target area of a body

2020. WO 2020/070492
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4.26 MB
Unit Publication
Little S
Brown P

Debugging adaptive deep brain stimulation for Parkinson's disease.

2020. Mov. Disord., 35(4):555-561.
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PMC7166127
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306.08 KB
Unit Publication
He S
Everest-Phillips C
Clouter A
Brown P
Tan H

Neurofeedback-Linked Suppression of Cortical β Bursts Speeds Up Movement Initiation in Healthy Motor Control: A Double-Blind Sham-Controlled Study.

2020. J. Neurosci., 40(20):4021-4032.
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PMC7219286
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1.89 MB
Unit Publication
McClelland VM
Cvetkovic Z
Lin JP
Mills KR
Brown P

Abnormal patterns of corticomuscular and intermuscular coherence in childhood dystonia.

2020. Clin. Neurophysiol., 131(4):967-977.
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PMC7083222
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1.54 MB
Unit Publication
Duchet B
Weerasinghe G
Cagnan H
Brown P
Bick C
Bogacz R

Phase-dependence of response curves to deep brain stimulation and their relationship: from essential tremor patient data to a Wilson-Cowan model.

2020. J. Math. Neurosci., 10(1):4.
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PMC7105566
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4.54 MB
Unit Publication
Fischer P
Lipski WJ
Neumann WJ
Turner R
Fries P
Brown P
Richardson RM

Movement-related coupling of human subthalamic nucleus spikes to cortical gamma.

2020. eLife, 9:e51956.
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PMC7096181
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1.95 MB
Unit Publication
Tinkhauser G
Torrecillos F
Pogosyan A
Mostofi A
Bange M
Fischer P
Tan H
Hasegawa H
Glaser M
Muthuraman M
Groppa S
Ashkan K
Pereira EA
Brown P

The Cumulative Effect of Transient Synchrony States on Motor Performance in Parkinson's Disease.

2020. J. Neurosci., 40(7):1571-1580.

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PMC7044725
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1.35 MB
Unit Publication
Khawaldeh S
Tinkhauser G
Shah SA
Petermann K
Debove I
Nguyen TAK
Nowacki A
Lachenmayer ML
Schuepbach M
Pollo C
Krack P
Woolrich M
Brown P

Subthalamic nucleus activity dynamics and limb movement prediction in Parkinson's disease.

2020. Brain, 143(2):582-596.
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PMC7009471
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1.1 MB