On 9th July, we met again with members of our Patient and Public Advisory Group to canvass their views on the Unit’s research direction and plans. The Advisory Group is made up of people with lived experience, as patients and carers, of diverse neurological and psychiatric conditions. The meeting started with Unit Director Professor Peter Magill giving a summary of a 15-year collective research vision. This was followed by a lively discussion and Q & A session with the Group, moderated by the Unit’s Patient and Public Involvement Lead Associate Professor Melanie Fleming. Conversations were centred around a range of topics, from patient needs and concerns to research priorities and on to emerging neurotechnology options for therapy.

Professor Magill commented, “Proactively involving the public helps ensure that our research tackles the most important healthcare challenges in the right ways to give greatest impact. The conversations with our Advisory Group were constructive and decisive, and their insights and steer were once again really helpful.”

Professor Fleming added, “This second meeting was another valuable opportunity to reflect on some key issues, and we look forward to working with our public partners again soon.”

Congratulations to Unit postdoctoral researcher Dr. Shenghong He on winning the Director’s Award for Public Engagement for 2024.

The Award recognises and celebrates the exemplary contributions of individuals or a small collective to the Unit’s extensive Outreach programme. The Award is given annually (this being the ninth occasion), on the basis of nominations made by Unit members.

Shenghong’s Award was announced by Unit Director Professor Peter Magill at a special ceremony held at the Unit’s Science Day last week.

Professor Magill commented “It gives us all great pleasure to reward Shenghong’s sterling contributions in this way. Shenghong has consistently demonstrated exceptional personal commitment to outreach. He developed a bespoke Brain-Computer Interface demonstration that has proven to be a fantastic tool for engaging diverse stakeholders, from school children to patient and carer groups. He plays a key role in organising engagement activities across the Unit, including our 2024 Open Day. He was one of the stars of the Unit’s research showcase video, The Symphony of the Brain, and he also helps curate the Unit’s social media content. A brilliant effort all around!”

The Unit held its eighteenth Science Day on Friday 5th July 2024. Unpublished work and future research projects were the focus of discussion, and Unit members and visitors enthusiastically took the chance to provide the constructive feedback needed for multidisciplinary team science.

There were 8 short talks and 17 poster presentations delivered by the Unit’s early-career researchers. Attendees were also treated to two Keynote Lectures: A first by Professor Penny Lewis of Cardiff University, in which she gave an engaging account of sleep engineering for health and cognition; and a second lecture by Professor Karunesh Ganguli of the University of California, San Francisco, in which he showcased the power of cross-species work to define the mechanisms underlying motor learning in health and in recovery from brain injury.

Unit Director Professor Peter Magill commented: “Another excellent opportunity to share ideas, know-how and data with colleagues, as well as to take stock of the Unit’s progress in synergistically integrating science, technology, engineering and mathematics into our research. The vigour of the whole community on the day was really uplifting.”

Our congratulations go to Unit D.Phil. student James Sermon for successfully defending his doctoral thesis, entitled “Modelling frequency-based neural responses to Deep Brain Stimulation in Parkinson's disease”, in his viva voce examination on 28th June 2024.

James’s viva examiners were Professor Anne Skeldon (University of Surrey) and Professor Mark Woolrich (University of Oxford).

James was supervised at the MRC BNDU by Professor Tim Denison, Dr Benoit Duchet and Professor Huiling Tan.

We are delighted to announce that the Unit has again achieved multiple accreditations through the Laboratory Efficiency Assessment Framework (LEAF), a nationally recognised scheme designed to improve the sustainability and efficiency of laboratories.

Seven laboratories at the Unit achieved accreditation for their sustainable practices. The Biomedical Services Facility gained a Bronze award for the first time. The Barron Group and Denison Group both renewed their Bronze awards. The Dupret Group, Sharott Group and Tan Group each enhanced their sustainability practices, gaining Silver awards for the first time. The Magill Group renewed its Silver award from last year.

To gain the awards, each Group was audited for the practical steps they had taken to meet several assessment criteria, including those related to the use of equipment and space, the management of samples and chemicals, ventilation, waste/recycling, and the engagement of colleagues.

Unit Director Professor Peter Magill commented “I am delighted that the Unit’s continued commitment to sustainable research has been recognised in this way. Congratulations to the many Unit members who worked together to identify and act on opportunities to help the Unit reduce its carbon emissions, waste and spend.”

Many congratulations to Unit members Dr. Yuhang Song, Dr. Shenghong He, and Associate Professor Melanie Fleming who each won prizes at this year’s Thomas Willis Day.

Thomas Willis Day (named after Thomas Willis (1621-1675), an Oxford-based pioneer in the field of brain research and neurology) is an annual event where staff and students from across the Nuffield Department of Clinical Neurosciences come together to celebrate the work of the Department.

Yuhang won the Early Career Researcher Prize in recognition of his paper “Inferring neural activity before plasticity as a foundation for learning beyond backpropagation”, published in Nature Neuroscience.

Shenghong won the Intermediate Career Researcher Prize in recognition of his paper “Beta-triggered adaptive deep brain stimulation during reaching movement in Parkinson's disease”, published in the journal Brain.

Melanie, who is the Unit’s Patient and Public Involvement Lead, won the Public Engagement Prize in recognition of her sustained excellence in promoting and delivering impactful public engagement/involvement activities across the Unit and wider Department.

Unit Postdoctoral Neuroscientist Dr. Joram van Rheede participated in the 'Spotlight on Engineering' public engagement talks at the Old Fire Station theatre in Oxford on the 17th April. The evening featured 6 speakers all giving 10-15 minute talks on engineering-related research. Joram presented on the interaction between deep brain stimulation therapy and sleep, highlighting research carried out by the Denison Group and Sharott Group at the Unit, as well as collaborations with the neurosurgical teams at the John Radcliffe Hospital, Great Ormond Street Hospital, and King’s College Hospital.

Joram commented, "It was great to work with colleagues from the Department of Engineering Science to put on a set of talks for a general audience. We participated in a public speaking workshop and practice sessions to help us craft a compelling narrative about our work, finding metaphors to explain important principles, and avoiding specialist jargon. The response from the audience was great- the questions were more stimulating than the ones we get at science conferences!"

We are pleased to welcome Dr. Helen Collins to the Unit as a Postdoctoral Neuroscientist in the Magill Group.

Helen holds a B.A. in Cell and Systems Biology, an M.Sc. in Neuroscience, and a D.Phil. from the University of Oxford. Helen’s doctoral research investigated the neurobiological mechanisms of selective serotonin reuptake inhibitor discontinuation syndrome in mice, using a range of behavioural and neurochemical techniques. After finishing her D.Phil. in 2023, Helen worked at a biotechnology company in Oxfordshire focused on developing novel treatments for Alzheimer’s; she led a small molecule drug discovery project and established the in vivo programme of work for a mouse model of the disease.

Here in the Unit, Helen will be using fibre photometry and electrophysiology in behaving mice to characterise the signalling dynamics of dopamine and other neuromodulators in the striatum in health and experimental Parkinsonism.

The Unit held its ninth annual Training & Careers Development Event on Tuesday 16th April. Unit members, together with colleagues from across the University of Oxford, were treated to a range of engaging presentations and workshops, each of which was accompanied by a lively Q & A session.

Unit Director Professor Peter Magill started the Event by recapping some key aspects of the Unit’s approach to training and career development. This was followed by an insightful joint presentation by Dr Anshul Thakur and Dr Elena Gal of the University Department of Engineering Science about the use of Artificial Intelligence and Large Language Models as research tools. Dr Susan Black of the University’s Careers Service then gave a talk and some welcome advice on honing interview skills.

In the first of two break-out workshops held after refreshments, Unit Group Leader Professor Charlotte Stagg led an interactive discussion about how to thrive at Oxford. In the second workshop, Unit Group Leader Professor Tim Denison chaired a session during which some of the Unit’s alumni offered their insights about thriving in careers in academia and industry outside of Oxford.

Professor Stagg, Chair of the Unit’s Training & Career Development Committee, commented “The training and career development of all our members is hugely important to the Unit, and we were delighted to host another successful training event at St Hilda’s College. Unit members actively engaged in a wide range of sessions, and we were particularly pleased to welcome back some of our wonderful alumni to speak about their career paths after leaving the Unit. Thank you to all our speakers and to the Committee for all their hard work.”

Our congratulations go to Unit D.Phil. student Beatriz Silveira de Arruda for successfully defending her doctoral thesis, entitled “Developing a non-invasive approach for the treatment of pathological tremor”, in her viva voce examination on 27th March 2024.

Beatriz’s viva examiners were Professor Simon Farmer (University College London) and Dr Ashwini Oswal (University of Oxford).

Beatriz was supervised by Professors Hayriye Cagnan, Tim Denison and Huiling Tan at the MRC BNDU.