Dupret Group

dupret

Firing response of hippocampal CA1 principal cells during sharp-wave/ripple events in sleep. Top trace, wide-band (1H–5 kHz) local field potential recorded in the pyramidal cell layer. Bottom trace, 140–250 Hz band pass-filtered local field potential highlighting ripple frequency events. Raster plots, spike times of simultaneously recorded CA1 principal cells (one cell per row). Note the firing synchrony during ripple events.

Our research group studies how neural activity in the hippocampus and connected brain regions supports memory-guided behaviour, enabling individuals to infer from past experience how to respond to ever-changing life situations.

Group Science

The idea that groups of distributed neurons transiently coordinate their spiking activity to organize information-representing cell assemblies is central to our investigations. Our laboratory uses a transdisciplinary approach that combines multichannel electrophysiological recordings during behaviour with optogenetic and real-time (closed-loop) manipulations of brain circuit dynamics. The group performs circuit-level analyses to: (i) determine how neural representations of the external world are computed, consolidated and recalled for the purpose of memory-guided behaviour; (ii) establish the mnemonic contribution of oscillatory patterns of network activity (e.g., theta, gamma, sharp wave/ripples); and (iii) define neuronal motifs and pathways supporting memory-guided behaviour. We perform this work while keeping in mind that not all memories serve adaptive behaviour. This is notably the case for memories that are related to experiences of drugs of abuse, and those memories that underpin maladaptive responses. Accordingly, our work is intended to provide principles of interventions aimed at rebalancing network physiopathology of maladaptive memory.

Key Research Areas
  • In vivo study of memory circuits

  • Mnemonic role of neuronal ensembles and oscillations

Research Techniques
  • Multichannel recordings and associated data analyses

  • Cell-type-selective and input-defined optogenetics

  • Memory-guided behaviour

Selected Publications
Unit Publication
Trouche S
Koren V
Doig NM
Ellender TJ
El-Gaby M
Lopes-Dos-Santos V
Reeve HM
Perestenko PV
Garas FN
Magill PJ
Sharott A
Dupret D
2019. Cell, 176:1393-1406.
Unit Publication
Lopes-Dos-Santos V
van de Ven GM
Morley A
Trouche S
Campo-Urriza N
Dupret D
2018. Neuron, 100(4):940–952.
Unit Publication
van de Ven GM
Trouche S
McNamara CG
Allen K
Dupret D
2016.Neuron, 92(5):968-974.
Unit Publication
Trouche S
Perestenko PV
van de Ven GM
Bratley CT
McNamara CG
Campo-Urriza N
Black SL
Reijmers LG
Dupret D

2016.Nat. Neurosci., 19(4):564-7.

McNamara CG
Tejero-Cantero Á
Trouche S
Campo-Urriza N
Dupret D
2014.Nat. Neurosci., 17(12):1658-60.
Datasets and resources

Like other Groups at the MRC BNDU, we are committed to best practice in open research.  We have created and curated a range of primary data, metadata and related resources that can be readily downloaded by external users from the MRC BNDU's Data Sharing Platform. We highlight below just a few examples of the datasets and other resources we have shared for the benefit of our stakeholders.

Lopes-dos-Santos V
van de Ven GM
Morley A
Trouche S
Campo-Urriza N
Dupret D