Investigating network dynamics of the human hippocampus
A wealth of studies conducted in rodents have established that temporally structured activity in the hippocampus network, analysed with respect to network oscillations and spike time relationships, supports memory-guided behaviour. How such a foundational knowledge discovered in rodents translates to the human hippocampus remains uncertain.
The overall aim of this PhD project is to investigate how hippocampal network activity support memory processes in humans. To achieve this goal, we will investigate patterns of network oscillations and spike time relationships of principal cells and interneurons recorded in the human hippocampus. This project will involve data collection from human participants, and advanced data analyses of network oscillations and spike trains of neuronal ensembles. Comparisons will be performed with respect to network dynamics of the rodent hippocampus, using existing datasets.
The project will take place in the Medical Research Council Brain Network Dynamics Unit at the University of Oxford, and will be conducted in collaboration with Dr. Leila Reddy based at the Brain and Cognition Research Center CERCO, Toulouse, France. The appointed student will benefit from the both the extensive generic and transdisciplinary skills training available within the Unit. As a whole, this particular project will expose you to a large array of techniques that are central to the field of Systems Neuroscience. Notably, you will receive advanced training in electrophysiological recordings of neuronal activity and multivariate data analyses (notably using graph-theoretical tools) and programming (Python, R, and Jupyter).
This Ph.D. (D.Phil.) studentship is funded by the Medical Research Council (MRC), a part of UKRI. The successful applicant is entitled to receive a tax-free stipend and, as a minimum, tuition fees paid at the Home level, regardless of whether they are Home or International students. Please see further details about MRC/UKRI studentships and guidance regarding Home and International eligibility. International students may be charged international level (‘Overseas’) fees by the University. Overseas fees are typically higher than Home level fees. See further details on fees at the University. Note that this MRC-funded studentship is not able to cover tuition fees above the Home level.
Interested candidates should possess, or expect to receive, a 1st class or upper 2nd class degree (or equivalent) in a related scientific discipline, e.g. biological or physical sciences, medicine, computer science, engineering, mathematics. Strong experience in programming for the purpose of data-driven science is required. Knowledge of advanced concepts and techniques in Systems Neuroscience is highly desirable.
We strongly encourage candidates to contact the project supervisor before submitting an application. To find out more about these MRC-funded studentships, the research project, and the application process, please contact Professor David Dupret by email on email@example.com. Professor Dupret is also happy to consider supervising PhD students funded by Departmental scholarships and other doctoral training programmes at Oxford, as well as PhD students with their own independent funding.
To be considered for one of these MRC-funded studentships, please submit an application for admission to the D.Phil. in the Nuffield Department of Clinical Neurosciences (course code RD_CU1), following the guidance. On the application form, in the section headed ‘Departmental Studentship Applications’, please indicate that you are applying for a studentship and enter the reference code for a MRC BNDU studentship "2022BNDUDTA".
The closing date for applications is 12.00 midday UK time on Friday 3rd December 2021.
Interviews for short-listed applicants will be held on Friday 7th and Monday 10th January 2022.
Applications are invited from both Home students and International students to join a multidisciplinary team of scientists studying hippocampal network-level mechanisms supporting memory processing in the mammalian brain. One MRC-funded studentship is available from the start of academic year 2022/23, for 3.5 years, and will be supervised by Professor David Dupret at the MRC BNDU, in collaboration with Dr. Leila Reddy from the CNRS, France.