Prof. Peter Brown

Recording of the local field potential activity in the human subthalamic nucleus during voluntary movement

Recording of the local field potential activity in the human subthalamic nucleus during voluntary movement. The magnitude of different frequencies at any moment in time is colour coded from blue to yellow (high). The overlaid black traces show movements made by a joystick held in the opposite hand. There is a reduction in activity in the nucleus before and during each movement. X and Y axes are time (10 second tick marks) and frequency (Hz), respectively.

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Prof. Peter Brown

Prof. Peter Brown

Emeritus Professor
Emeritus MRC Investigator

Peter Brown is an emeritus Professor of Experimental Neurology in the Nuffield Department of Clinical Neurosciences, University of Oxford, and the founding Director of the MRC Brain Network Dynamics Unit at the University of Oxford.

Peter graduated in Medicine at the University of Cambridge. He was appointed a Professor of Neurology at University College London in 2004, and in 2006, he became Head of the Sobell Department of Motor Neuroscience and Movement Disorders at the Institute of Neurology, University College London. He moved to the Nuffield Department of Clinical Neurosciences at the University of Oxford as Professor of Experimental Neurology in 2010, and in 2015, became the first Director of the MRC BNDU. He retired in 2021.

Peter began his research in disorders of movement in the early 1990s, when he was instrumental in classifying and determining the underlying pathophysiology of myoclonus, and the stiff person and startle syndromes. Subsequently, Peter developed an interest in the pathophysiology of Parkinson’s disease, establishing that synchronised oscillations amongst nerve cells in the basal ganglia of the brains of people with Parkinson’s are linked to symptoms of stiffness and slowness, and successfully pioneering therapeutic interventions that leverage this phenomenon.

 

Selected Publications
Unit Publication
Khawaldeh S
Tinkhauser G
Shah SA
Petermann K
Debove I
Nguyen TAK
Nowacki A
Lachenmayer ML
Schuepbach M
Pollo C
Krack P
Woolrich M
Brown P
2020. Brain, 143(2):582-596.
Unit Publication
Torrecillos F
Falato E
Pogosyan A
West TO
Di Lazzaro V
Brown P
2020. J. Neurosci., 40(2):369-381.
Unit Publication
Herz DM
Little S
Pedrosa D
Tinkhauser G
Cheeran B
Foltynie T
Bogacz R
Brown P
2018. Curr. Biol., 28(8):1169-1178.e6.
Unit Publication
Tinkhauser G
Pogosyan A
Little S
Beudel M
Herz DM
Tan H
Brown P
2017. Brain, 140(4):1053-1067.
Unit Publication
Cagnan H
Pedrosa D
Little S
Pogosyan A
Cheeran B
Aziz TZ
Green AL
Fitzgerald J
Foltynie T
Limousin P
Zrinzo L
Hariz M
Friston KJ
Denison T
Brown P
2017. Brain, 140(1):132-145.