Combining Multimodal Biomarkers to Guide Deep Brain Stimulation Programming in Parkinson Disease.
After deep brain stimulation (DBS) surgery for Parkinson’s, stimulation settings must be optimised with programming to best manage patients’ symptoms. Currently, DBS stimulation programming is a manual and time-consuming procedure. Here, we used an algorithm and different information (brain signals, imaging data and clinical evaluations) to predict the most relevant DBS settings. This method should help automate and facilitate DBS programming in the future.
Deep brain stimulation (DBS) programming of multicontact DBS leads relies on a very time-consuming manual screening procedure, and strategies to speed up this process are needed. Beta activity in subthalamic nucleus (STN) local field potentials (LFP) has been suggested as a promising marker to index optimal stimulation contacts in patients with Parkinson disease.
2023. Neuromodulation, 26(2):320-332.
2017.Mov. Disord., 32(6):810-819.