Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients.

Huang Y
Sun B
Debarros J
Zhang C
Zhan S
Li D
Zhang C
Wang T
Huang P
Lai Y
Brown P
Cao C
Tan H

Understanding how emotional stimuli affect brain activity can offer insights into psychiatric disorders. Here, we observed brief increases in special brain rhythms when people with psychiatric disorders viewed unpleasant pictures as compared to pleasant pictures. Our results suggest that rhythmic nerve cell activity in deep parts of the brain is involved in perceiving and processing negative emotions.

Scientific Abstract

Lateral habenula is believed to encode negative motivational stimuli and plays key roles in the pathophysiology of psychiatric disorders. However, how habenula activities are modulated during the processing of emotional information is still poorly understood. We recorded local field potentials from bilateral habenula areas with simultaneous cortical magnetoencephalography in nine patients with psychiatric disorders during an emotional picture-viewing task. Transient activity in the theta/alpha band (5-10 Hz) within the habenula and prefrontal cortical regions, as well as the coupling between these structures, is increased during the perception and processing of negative emotional stimuli compared to positive emotional stimuli. The increase in theta/alpha band synchronization in the frontal cortex-habenula network correlated with the emotional valence but not the arousal score of the stimuli. These results provide direct evidence for increased theta/alpha synchrony within the habenula area and prefrontal cortex-habenula network in the perception of negative emotion in human participants.

At the top, and lower left, are three coloured pictures of the frequency content of brain rhythms. On the lower right, there is brain scan to which colours have been added.
Negative emotional stimuli, compared to positive emotional stimuli, induced higher activities in the theta/alpha frequency band (5-10 Hz) in the prefrontal cortex and the habenula, as well as increased synchrony (coherence) between alpha/theta rhythms in these two brain structures.
2021. eLife, 10:e65444.
He S, Mostofi A, Syed EC, Torrecillos F, Tinkhauser G, Fischer P, Pogosyan A, Hasegawa H, Li Y, Ashkan K, Pereira EA, Brown P, Tan H
2020. eLife, 9:e60979.
Tinkhauser G, Torrecillos F, Pogosyan A, Mostofi A, Bange M, Fischer P, Tan H, Hasegawa H, Glaser M, Muthuraman M, Groppa S, Ashkan K, Pereira EA, Brown P

2020. J. Neurosci., 40(7):1571-1580.

Khawaldeh S, Tinkhauser G, Torrecillos F, He S, Foltynie T, Limousin P, Zrinzo L, Oswal A, Quinn AJ, Vidaurre D, Tan H, Litvak V, Kühn AA, Woolrich M, Brown P
2021. Brain : in press.
Bocchio M, Fucsina G, Oikonomidis L, McHugh SB, Bannerman DM, Sharp T, Capogna M
2015.Neuropsychopharmacology, 40(13):3015-26.
Tinkhauser G, Torrecillos F, Duclos Y, Tan H, Pogosyan A, Fischer P, Carron R, Welter ML, Karachi C, Vandenberghe W, Nuttin B, Witjas T, Régis J, Azulay JP, Eusebio A, Brown P
2018. Neurobiol. Dis., 117(Sept):217-225.