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2023

Unit Publication
Herz DM
Bange M
Gonzalez-Escamilla G
Auer M
Muthuraman M
Glaser M
Bogacz R
Pogosyan A
Tan H
Groppa S
Brown P

Dynamic modulation of subthalamic nucleus activity facilitates adaptive behavior.

2023. PLoS Biol, 21(6)e3002140.

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PMC10234560
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2.88 MB
Unit Publication
Wiest C
Torrecillos F
Pogosyan A
Bange M
Muthuraman M
Groppa S
Hulse N
Hasegawa H
Ashkan K
Baig F
Morgante F
Pereira EA
Mallet N
Magill PJ
Brown P
Sharott A
Tan H

The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism.

2023. eLife, 12:e82467

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PMC10005762
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1.17 MB
Unit Publication
Shah A
Nguyen TAK
Petermann K
Khawaldeh S
Debove I
Shah SA
Torrecillos F
Tan H
Pogosyan A
Lachenmayer ML
Michelis J
Brown P
Pollo C
Krack P
Nowacki A
Tinkhauser G

Combining Multimodal Biomarkers to Guide Deep Brain Stimulation Programming in Parkinson Disease.

2023. Neuromodulation, 26(2):320-332.

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PMC7614142
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2.07 MB

2022

Unit Publication
Torrecillos F
Tan H
Brown P
Capone F
Ricciuti R
Di Lazzaro V
Marano M

Non-invasive vagus nerve stimulation modulates subthalamic beta activity in Parkinson's disease.

2022. Brain Stimul, 15(6):1513-1516.

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PMC7613925
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811.48 KB
Unit Publication
Herz DM
Bange M
Gonzalez-Escamilla G
Auer M
Ashkan K
Fischer P
Tan H
Bogacz R
Muthuraman M
Groppa S
Brown P

Dynamic control of decision and movement speed in the human basal ganglia.

2022. Nat Commun, 13(1):7530.

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PMC9729212
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2.48 MB
Unit Publication
Khawaldeh S
Tinkhauser G
Torrecillos F
He S
Foltynie T
Limousin P
Zrinzo L
Oswal A
Quinn AJ
Vidaurre D
Tan H
Litvak V
Kühn AA
Woolrich M
Brown P

Balance between competing spectral states in subthalamic nucleus is linked to motor impairment in Parkinson's disease.

2022. Brain, 145(1):237-250.

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PMC8967096
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1.33 MB

2021

Unit Publication
Fischer P
He S
Tan H
Brown P

Patent Application: Treatment of gait impairment using deep brain stimulation

2021. WO/2021/250398
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2.35 MB
Unit Publication
He S
Deli A
Fischer P
Wiest C
Huang Y
Martin S
Khawaldeh S
Aziz TZ
Green AL
Brown P
Tan H

Gait-Phase Modulates Alpha and Beta Oscillations in the Pedunculopontine Nucleus.

2021. J Neurosci, 41(40):8390-8402.

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PMC8496192
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3.18 MB
Unit Publication
Huang Y
Sun B
Debarros J
Zhang C
Zhan S
Li D
Zhang C
Wang T
Huang P
Lai Y
Brown P
Cao C
Tan H

Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients.

2021. eLife, 10:e65444

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PMC8275130
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3.7 MB
Unit Publication
He S
Baig F
Mostofi A
Pogosyan A
Debarros J
Green AL
Aziz TZ
Pereira EA
Brown P
Tan H

Closed-Loop Deep Brain Stimulation for Essential Tremor Based on Thalamic Local Field Potentials.

2021. Mov Disord, 36(4):863-873.

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PMC7610625
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1.43 MB
Unit Publication
Wiest C
Tinkhauser G
Pogosyan A
He S
Baig F
Morgante F
Mostofi A
Pereira EA
Tan H
Brown P
Torrecillos F

Subthalamic deep brain stimulation induces finely-tuned gamma oscillations in the absence of levodopa.

2021. Neurobiol Dis, 152:105287.

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PMC7116781
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10.76 MB

2020

Unit Publication
Debarros J
Brown P
Tan H
Denison T

Patent Granted: Emulation of electrophysiological signals derived by stimulation of a body

2020. WO/2020/165591
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4.48 MB
Unit Publication
He S
Mostofi A
Syed EC
Torrecillos F
Tinkhauser G
Fischer P
Pogosyan A
Hasegawa H
Li Y
Ashkan K
Pereira EA
Brown P
Tan H

Subthalamic beta-targeted neurofeedback speeds up movement initiation but increases tremor in Parkinsonian patients.

2020. eLife, 9:e60979.
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PMC7695453
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1.9 MB
Unit Publication
Fischer P
He S
de Roquemaurel A
Akram H
Foltynie T
Limousin P
Zrinzo L
Hyam J
Cagnan H
Brown P
Tan H

Entraining stepping movements of Parkinson's patients to alternating subthalamic nucleus deep brain stimulation.

2020. J. Neurosci., 40(46):8964–8972.
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PMC7659462
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1017.91 KB
Unit Publication
Wiest C
Tinkhauser G
Pogosyan A
Bange M
Muthuraman M
Groppa S
Baig F
Mostofi A
Pereira EA
Tan H
Brown P
Torrecillos F

Local field potential activity dynamics in response to deep brain stimulation of the subthalamic nucleus in Parkinson's disease.

2020. Neurobiol. Dis., 143:105019.
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PMC7115855
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4.15 MB
Unit Publication
Yeh CH
Al-Fatly B
Kühn AA
Meidahl AC
Tinkhauser G
Tan H
Brown P

Waveform changes with the evolution of beta bursts in the human subthalamic nucleus.

2020. Clin. Neurophysiol., 131(9):2086-2099.
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PMC7115847
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1.62 MB
Unit Publication
Debarros J
Brown P
Tan H

Patent Granted: Measurement of electrophysiological signals during stimulation of a target area of a body

2020. WO/2020/070492
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4.26 MB
Unit Publication
He S
Everest-Phillips C
Clouter A
Brown P
Tan H

Neurofeedback-Linked Suppression of Cortical β Bursts Speeds Up Movement Initiation in Healthy Motor Control: A Double-Blind Sham-Controlled Study.

2020. J. Neurosci., 40(20):4021-4032.
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PMC7219286
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1.89 MB
Unit Publication
Tinkhauser G
Torrecillos F
Pogosyan A
Mostofi A
Bange M
Fischer P
Tan H
Hasegawa H
Glaser M
Muthuraman M
Groppa S
Ashkan K
Pereira EA
Brown P

The Cumulative Effect of Transient Synchrony States on Motor Performance in Parkinson's Disease.

2020. J. Neurosci., 40(7):1571-1580.

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PMC7044725
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1.35 MB

2019

Unit Publication
Chen CC
Yeh CH
Chan HL
Chang YJ
Tu PH
Yeh CH
Lu CS
Fischer P
Tinkhauser G
Tan H
Brown P

Subthalamic nucleus oscillations correlate with vulnerability to freezing of gait in patients with Parkinson's disease.

2019. Neurobiol. Dis., 132:104605.
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PMC6764839
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1.52 MB
Unit Publication
Lofredi R
Tan H
Neumann WJ
Yeh CH
Schneider GH
Kühn AA
Brown P

Beta bursts during continuous movements accompany the velocity decrement in Parkinson's disease patients.

2019. Neurobiol. Dis., 127:462-471.
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PMC6520224
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1.48 MB
Unit Publication
Fischer P
Pogosyan A
Green AL
Aziz TZ
Hyam J
Foltynie T
Limousin P
Zrinzo L
Samuel M
Ashkan K
Da Lio M
De Cecco M
Fornaser A
Brown P
Tan H

Beta synchrony in the cortico-basal ganglia network during regulation of force control on and off dopamine.

2019. Neurobiol. Dis., 127:253-263.
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PMC6517271
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1.74 MB
Unit Publication
Tan H
Debarros J
He S
Pogosyan A
Aziz TZ
Huang Y
Wang S
Timmermann L
Visser-Vandewalle V
Pedrosa D
Green AL
Brown P

Decoding voluntary movements and postural tremor based on thalamic LFPs as a basis for closed-loop stimulation for essential tremor.

2019. Brain Stimul., 12(4):858-867.
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PMC6600875
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2.18 MB

2018

Unit Publication
Tan H
Fischer P
Shah SA
Vidaurre D
Woolrich M
Brown P

Decoding Movement States in Stepping Cycles Based on Subthalamic LFPs in Parkinsonian Patients.

2018. Conf Proc IEEE Eng Med Biol Soc, 2018:1384-1387.
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PMC6277015
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2.51 MB
Unit Publication
Torrecillos F
Tinkhauser G
Fischer P
Green AL
Aziz TZ
Foltynie T
Limousin P
Zrinzo L
Ashkan K
Brown P
Tan H

Modulation of Beta Bursts in the Subthalamic Nucleus Predicts Motor Performance.

2018. J. Neurosci., 38(41):8905-8917.
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PMC6181312
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1.29 MB