Dopamine and Consolidation of Episodic Memory: Timing Is Everything.

Grogan J
Bogacz R
Tsivos D
Whone AL
Coulthard EJ

The effect of dopaminergic medications on the consolidation of memory in people with Parkinson's disease depends on how soon after learning they are given the medication. Here, we show that dopaminergic medications impair early consolidation of episodic memory, but enhance late memory consolidation.

Scientific Abstract

Memory consolidation underpins adaptive behavior and dopaminergic networks may be critical for prolonged, selective information storage. To understand the time course of the dopaminergic contribution to memory consolidation in humans, here we investigate the effect of dopaminergic medication on recall and recognition in the short and longer term in Parkinson disease (PD). Fifteen people with PD were each tested on or off dopaminergic medication during learning/early consolidation (Day 1) and/or late consolidation (Day 2). Fifteen age-matched healthy participants were tested only once. On Day 1 participants learned new information, and early episodic memory was tested after 30 min. Then on Day 2, recall and recognition were retested after a 24-hr delay. Participants on medication on Day 1 recalled less information at 30 min and 24 hr. In contrast, patients on medication on Day 2 (8-24 hr after learning) recalled more information at 24 hr than those off medication. Although recognition sensitivity was unaffected by medication, response bias was dependent on dopaminergic state: Medication during learning induced a more liberal bias 24 hr later, whereas patients off medication during learning were more conservative responders 24 hr later. We use computational modeling to propose possible mechanisms for this change in response bias. In summary, dopaminergic medication in PD patients during learning impairs early consolidation of episodic memory and makes delayed responses more liberal, but enhances late memory consolidation presumably through a dopamine-dependent consolidation pathway that may be active during sleep.

Retention of memories at different delays after learning for healthy controls and Parkinson's patients on or off medications at the two delays.
Retention of memories at different delays after learning for healthy controls and Parkinson's patients on or off medications at the two delays.

2015.J Cogn Neurosci, 27(10):2035-50.

Related Content
Grogan J, Tsivos D, Smith L, Knight BE, Bogacz R, Whone AL, Coulthard EJ
2017. eLife;6:e26801
Kosillo P, Doig NM, Ahmed KM, Agopyan-Miu AHCW, Wong CD, Conyers L, Threlfell S, Magill PJ, Bateup HS
2019. Nat. Commun., 10(1):5426.
Tinkhauser G, Torrecillos F, Pogosyan A, Mostofi A, Bange M, Fischer P, Tan H, Hasegawa H, Glaser M, Muthuraman M, Groppa S, Ashkan K, Pereira EA, Brown P

2020. J. Neurosci., 40(7):1571-1580.