Basal ganglia-cortical interactions in Parkinsonian patients.

Marreiros AC
Cagnan H
Moran RJ
Friston KJ
Brown P
Scientific Abstract

Parkinson's disease is a common and debilitating condition, caused by aberrant activity in a complex basal ganglia-thalamocortical circuit. Therapeutic advances rely on characterising interactions in this circuit. However, recording electrophysiological responses over the entire circuit is impractical. Dynamic causal modelling offers large-scale models of predictive value based on a limited or partial sampling of complex networks. Using dynamic causal modelling, we determined the network changes underlying the pathological excess of beta oscillations that characterise the Parkinsonian state. We modelled data from five patients undergoing surgery for deep brain stimulation of more than one target. We found that connections to and from the subthalamic nucleus were strengthened and promoted beta synchrony, in the untreated compared to the treated Parkinsonian state. Dynamic causal modelling was able to replicate the effects of lesioning this nucleus and may provide a new means of directing the search for therapeutic targets.


2013.Neuroimage, 66():301-10.

Shah SA, Tan H, Brown P
2016. Conf Proc IEEE Eng Med Biol Soc, 2016(): 5717-5720.
Cagnan H, Mallet N, Moll CK, Gulberti A, Holt AB, Westphal M, Gerloff C, Engel AK, Hamel W, Magill PJ, Brown P, Sharott A
2019. Proc. Natl. Acad. Sci. U.S.A., 116:16095-16104.
Tan H, Fischer P, Shah SA, Vidaurre D, Woolrich M, Brown P
2018. Conf Proc IEEE Eng Med Biol Soc, 2018:1384-1387.
He S, Mostofi A, Syed EC, Torrecillos F, Tinkhauser G, Fischer P, Pogosyan A, Hasegawa H, Li Y, Ashkan K, Pereira EA, Brown P, Tan H
2020. eLife, 9:e60979.
Fischer P
2021. eNeuro, (Apr 19):ENEURO.0009-21.2021.