Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats.

Kaya AH
Vlamings R
Tan S
Lim LW
Magill PJ
Steinbusch HW
Visser-Vandewalle V
Sharp T
Temel Y
Scientific Abstract

Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.

Citation

2008.Brain Res., 1221():93-7.

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