Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients.

Eusebio A

Thevathasan W

Doyle Gaynor L

Pogosyan A

Bye E

Foltynie T

Zrinzo L

Ashkan K

Aziz TZ

Brown P

Scientific Abstract

Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity.

Citation

2011.J. Neurol. Neurosurg. Psychiatry, 82(5):569-73.

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