Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients.

Eusebio A
Thevathasan W
Doyle Gaynor L
Pogosyan A
Bye E
Foltynie T
Zrinzo L
Ashkan K
Aziz TZ
Brown P
Scientific Abstract

Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity.


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