Dendritic Integration of Sensory Evidence in Perceptual Decision-Making.

Groschner LN
Chan Wah Hak L
Bogacz R
DasGupta S
Miesenböck G

As we make decisions between alternative options, our brains accumulate evidence for one option over another. Exactly how this process of evidence accumulation is represented in nerve cell activity is unclear. Here, we collaborated with scientists working on fruit fly brains to shed new light on the ways that specialised nerve cells assimilate information from other cells to guide decision making.

Scientific Abstract

Perceptual decisions require the accumulation of sensory information to a response criterion. Most accounts of how the brain performs this process of temporal integration have focused on evolving patterns of spiking activity. We report that subthreshold changes in membrane voltage can represent accumulating evidence before a choice. αβ core Kenyon cells (αβ KCs) in the mushroom bodies of fruit flies integrate odor-evoked synaptic inputs to action potential threshold at timescales matching the speed of olfactory discrimination. The forkhead box P transcription factor (FoxP) sets neuronal integration and behavioral decision times by controlling the abundance of the voltage-gated potassium channel Shal (K4) in αβ KC dendrites. αβ KCs thus tailor, through a particular constellation of biophysical properties, the generic process of synaptic integration to the demands of sequential sampling.

During the course of decision making process, evidence for one option over another is accumulated over time (top left). Response is triggered when sufficient amount of information is gathered (bottom left). The membrane potential of a particular group of neurons in fruit fly brain (top right) reflects the evidence accumulated by the animal during the decision process (bottom right).
During the course of decision making process, evidence for one option over another is accumulated over time (top left). Response is triggered when sufficient amount of information is gathered (bottom left). The membrane potential of a particular group of neurons in fruit fly brain (top right) reflects the evidence accumulated by the animal during the decision process (bottom right).
Citation
2018. Cell, 173(4):894-905.
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