Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson's disease.

Litvak V
Jha A
Eusebio A
Oostenveld R
Foltynie T
Limousin P
Zrinzo L
Hariz M
Friston KJ
Brown P
Scientific Abstract

Both phenotype and treatment response vary in patients with Parkinson's disease. Anatomical and functional imaging studies suggest that individual symptoms may represent malfunction of different segregated networks running in parallel through the basal ganglia. In this study, we use a newly described, electrophysiological method to describe cortico-subthalamic networks in humans. We performed combined magnetoencephalographic and subthalamic local field potential recordings in thirteen patients with Parkinson's disease at rest. Two spatially and spectrally separated networks were identified. A temporoparietal-brainstem network was coherent with the subthalamic nucleus in the alpha (7-13 Hz) band, whilst a predominantly frontal network was coherent in the beta (15-35 Hz) band. Dopaminergic medication modulated the resting beta network, by increasing beta coherence between the subthalamic region and prefrontal cortex. Subthalamic activity was predominantly led by activity in the cortex in both frequency bands. The cortical topography and frequencies involved in the alpha and beta networks suggest that these networks may be involved in attentional and executive, particularly motor planning, processes, respectively.

Citation

2011.Brain, 134(Pt 2):359-74.

More Like This
Publication
Herz DM, Tan H, Brittain JS, Fischer P, Cheeran B, Green AL, Fitzgerald J, Aziz TZ, Ashkan K, Little S, Foltynie T, Limousin P, Zrinzo L, Bogacz R, Brown P
2017. eLife, 6:e21481
Unit Publication
Publication
Chen CC, Yeh CH, Chan HL, Chang YJ, Tu PH, Yeh CH, Lu CS, Fischer P, Tinkhauser G, Tan H, Brown P
2019. Neurobiol. Dis., 132:104605.
Unit Publication
Publication
Herz DM, Little S, Pedrosa D, Tinkhauser G, Cheeran B, Foltynie T, Bogacz R, Brown P
2018. Curr. Biol., 28(8):1169-1178.e6.
Unit Publication
Publication
Jha A, Litvak V, Taulu S, Thevathasan W, Hyam J, Foltynie T, Limousin P, Bogdanovic M, Zrinzo L, Green AL, Aziz TZ, Friston KJ, Brown P

2017.Cereb. Cortex, 27(1):54-67.

Unit Publication
Publication
Oswal A, Beudel M, Zrinzo L, Limousin P, Hariz M, Foltynie T, Litvak V, Brown P
2016. Brain, 139:1482-96.
Unit Publication