A mechanism for hippocampal memory recall based on excitatory-inhibitory fluctuations in neocortex

Koolschijn RS
Shpektor A
Ip IB
Clarke WT
Dupret D
Emir UE
Barron HC
Scientific Abstract

The brain has a remarkable capacity to acquire and store memories that can later be selectively recalled. These processes are supported by the hippocampus which is thought to index memory recall by reinstating information stored across distributed neocortical circuits. However, the mechanism that supports this interaction remains unclear. Here, in humans, we show that recall of a visual cue from a paired associate is accompanied by a transient increase in the ratio between glutamate and GABA in visual cortex. Moreover, these excitatory-inhibitory fluctuations are predicted by activity in the hippocampus. These data suggest the hippocampus gates memory recall by indexing information stored across neocortical circuits using a disinhibitory mechanism.

Citation
bioRxiv, 10.1101/2020.11.27.401299
DOI
10.1101/2020.11.27.401299
More Like This
Publication
Barron HC, Vogels TP, Behrens TE, Ramaswami M
2017.Proc. Natl. Acad. Sci. U.S.A., 114(26):6666-6674.
Unit Publication
Publication
He S, Baig F, Mostofi A, Pogosyan A, Debarros J, Green AL, Aziz TZ, Pereira EA, Brown P, Tan H
2021. Mov Disord, 36(4):863-873.
Unit Publication
Publication
Tan H, Debarros J, He S, Pogosyan A, Aziz TZ, Huang Y, Wang S, Timmermann L, Visser-Vandewalle V, Pedrosa D, Green AL, Brown P
2019. Brain Stimul., 12(4):858-867.
Unit Publication
Publication
Koolschijn RS, Emir UE, Pantelides AC, Nili H, Behrens TE, Barron HC
2019. Neuron 101:528-541
Unit Publication
Publication
Tan H, Fischer P, Shah SA, Vidaurre D, Woolrich M, Brown P
2018. Conf Proc IEEE Eng Med Biol Soc, 2018:1384-1387.
Unit Publication