Ben Micklem

Neurons in the cortex labelled by Golgi impregnation.

Neurons in the cortex labelled by Golgi impregnation.

micklem

Ben Micklem

Research Support Manager

Ben's areas of expertise include digital 3D neuron reconstruction, stereology, laser scanning confocal microscopy, and correlated light and electron microscopy. Highlights of the research outcomes of applying these techniques include:

  • Illustrated and quantified with 3D reconstruction the discovery of the axonal distribution of a new population of globus pallidus neurons that re-defined the nucleus's role in the basal ganglia circuit (Mallet et al 2012).
  • Helped to devise a stereological approach to quantifying number and distribution of all synaptic inputs to a single identified neuron using electron microscopy (Henny et al 2014).
  • Quantified the density and distribution of neuronal sub-populations of the peduncular-pontine nucleus (Mena-Segovia et al 2009; Martinez-Gonzalez et al 2012).

Ben manages the Unit's microscopy facilities, which include a Hitachi HT7800 120kV TEM installed in 2018, a Zeiss LSM880 laser scanning confocal microscope, and two fully motorised epi-fluorescent microscopes with structured illumination. Responsibilities include identifying microscopy techniques and equipment to meet the Unit's research needs, procurement, maintenance, and training.

He is passionate about science communication and outreach, has guided the development of this web site, and has produced video abstracts to highlight the Unit's research. The images (right) are a selection of journal covers that he has designed.

Ben graduated from the University of Nottingham in 2002 with a degree in biology. He began working at the MRC Anatomical Neuropharmacology Unit (the predecessor to the current BNDU) in 2003 as an Imaging and Microscopy Technician. In 2005 he was awarded a Graduate Imaging Scientist qualification and an Associateship by the Royal Photographic Society. His professional passion for imaging spills over into his personal interests in photography and videography of the natural world.

The Hippocampal Escapement- Neuron cover May 21, 2014

The Hippocampal Escapement- Neuron cover May 21, 2014

Neuron Ivy Cell Cover 2008

Neuron Ivy Cell Cover 2008

August 1st 2007 cover of Journal of Neuroscience

August 1st 2007 cover of Journal of Neuroscience

Journal of Neuroscience cover 2007

Journal of Neuroscience cover 2007

3D reconstruction of a large intercalated (L-ITC) neuron (TJX-31A) recorded in the amygdala of an adult rat in vivo. Reconstruction by Daniela Busti and Ben Micklem.

3D reconstruction of a large intercalated (L-ITC) neuron (TJX-31A) recorded in the amygdala of an adult rat in vivo. Reconstruction by Daniela Busti and Ben Micklem.

Additional cover designs.

Additional cover designs.

Selection of Journal Covers

Selection of Journal Covers

Recent Publications

Katona L
Micklem BR
Borhegyi Z
Swiejkowski DA
Valenti O
Viney TJ
Kotzadimitriou D
Klausberger T
Somogyi P

2017.Hippocampus, 27(4):359-377.

Bienvenu TC
Busti D
Micklem BR
Mansouri M
Magill PJ
Ferraguti F
Capogna M

2015.J. Neurosci., 35(5):2044-57.

Henny P
Brown MT
Micklem BR
Magill PJ
Bolam JP

2014.Brain Struct Funct, 219(2):631-40.

Katona L
Lapray D
Viney TJ
Oulhaj A
Borhegyi Z
Micklem BR
Klausberger T
Somogyi P

2014.Neuron, 82(4):872-86.