Brown Group

Group Science

The group takes a multidisciplinary approach combining experimental manipulations in healthy subjects and patients with sophisticated signals analysis and modelling. Our experimental manipulations include non-invasive brain stimulation and often involve patients who have had deep brain stimulation electrodes implanted as treatment for problems with movement. Over the years we have made major advances in understanding how abnormal interactions between brain cells cause slowness of movement, tremor and stiffness in patients with Parkinson’s Disease. Our ultimate goal is to capitalise on these discoveries to improve treatment in Parkinson’s Disease and other illnesses where similar principles apply.

Key Research Areas: 
Functional connectivity within subcortico-cortical motor loops in disease
Functional connectivity within subcortico-cortical motor loops in health
Therapy for movement disorders
Longer-term Perspectives: 
We are at the beginning of a therapeutic revolution whereby we can interact with neural dynamics from moment-to-moment as necessary to reverse or ameliorate dysfunctional brain activity. To this end we must record and interpret brain signals in real-time with sufficient temporal and spatial resolution to give nuanced control. Although electrical brain stimulation is already affording major therapeutic benefits, there is vast scope for improving and extending this to provide adaptive and tailored interventions, and for harnessing genetic advances that enable cell-type specific stimulation.
Adaptive stimulation in patients with Parkinson's Disease using local field potential