Reshaping the path of vascular cognitive impairment with resistance training: a study protocol for a randomized controlled trial.

Liu-Ambrose T
Dao E
Crockett RA
Barha CK
Falck RS
Best JR
Hsiung GR
Field TS
Madden KM
Alkeridy W
Boa Sorte Silva NC
Davis JC
Ten Brinke L
Doherty S
Tam R
Scientific Abstract

Subcortical ischemic vascular cognitive impairment (SIVCI) is the most common form of vascular cognitive impairment. Importantly, SIVCI is considered the most treatable form of cognitive impairment in older adults, due to its modifiable risk factors such as hypertension, diabetes mellitus, and hypercholesterolemia. Exercise training is a promising intervention to delay the progression of SIVCI, as it actively targets these cardiometabolic risk factors. Despite the demonstrated benefits of resistance training on cognitive function and emerging evidence suggesting resistance training may reduce the progression of white matter hyperintensities (WMHs), research on SIVCI has predominantly focused on the use of aerobic exercise. Thus, the primary aim of this proof-of-concept randomized controlled trial is to investigate the efficacy of a 12-month, twice-weekly progressive resistance training program on cognitive function and WMH progression in adults with SIVCI. We will also assess the efficiency of the intervention.

Eighty-eight community-dwelling adults, aged > 55 years, with SIVCI from metropolitan Vancouver will be recruited to participate in this study. SIVCI will be determined by the presence of cognitive impairment (Montreal Cognitive Assessment < 26) and cerebral small vessel disease using computed tomography or magnetic resonance imaging. Participants will be randomly allocated to a twice-weekly exercise program of (1) progressive resistance training or (2) balance and tone training (i.e., active control). The primary outcomes are cognitive function measured by the Alzheimer's Disease Assessment Scale-Cognitive-Plus (ADAS-Cog-13 with additional cognitive tests) and WMH progression.

The burden of SIVCI is immense, and to our knowledge, this will be the first study to quantify the effect of progressive resistance training on cognitive function and WMH progression among adults with SIVCI. Slowing the rate of cognitive decline and WMH progression could preserve functional independence and quality of life. This could lead to reduced health care costs and avoidance of early institutional care. NCT02669394 . Registered on February 1, 2016.


2021. Trials, 22(1):217.

Related Content
He S, Everest-Phillips C, Clouter A, Brown P, Tan H
2020. J. Neurosci., 40(20):4021-4032.
Gillies MJ, Hyam JA, Weiss AR, Antoniades CA, Bogacz R, Fitzgerald JJ, Aziz TZ, Whittington MA, Green AL

2017.Exp Brain Res, 235(5):1455-1465.

Schoenfeld MJ, Thom J, Williams J, Stagg CJ, Zich C

2024. Eur J Neurosci, 59(1):54-68.