The acute brain response to levodopa heralds dyskinesias in Parkinson disease.

Herz DM
Haagensen BN
Christensen MS
Madsen KH
Rowe JB
Løkkegaard A
Siebner HR
Scientific Abstract

In Parkinson disease (PD), long-term treatment with the dopamine precursor levodopa gradually induces involuntary "dyskinesia" movements. The neural mechanisms underlying the emergence of levodopa-induced dyskinesias in vivo are still poorly understood. Here, we applied functional magnetic resonance imaging (fMRI) to map the emergence of peak-of-dose dyskinesias in patients with PD.

Citation

2014.Ann. Neurol., 75(6):829-36.

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