Key Research Areas:
Mechanisms underlying neuronal network activity in basal ganglia-thalamocortical circuits.
Cell-type-specific encoding of behaviour in basal ganglia-thalamocortical circuits.
Experimental models of movement/memory disorders involving basal ganglia-thalamocortical circuits.
Generation, dissemination and impact of aberrant neuronal oscillations in the Parkinsonian brain.
Cell-type-specific interventions for symptom relief in disease.
Our research is designed to provide significant advances in the understanding of how specialised cell types in the basal ganglia work together with neurons in their partner brain circuits to control behaviour, for better or worse. We recognise that new understanding is critically important for building a stronger foundation from which to develop new therapeutic interventions in disease. We thus strive to progress from delivering new mechanistic insights, through generation of firm rationale to proof-of-concept studies that can be taken forward to inform and advance the future development of improved, personalised therapies.
Electrophysiology (in vivo and in vitro)
Single-cell recording/labelling in vivo
Light and electron microscopy
Genetics-based approaches for cell monitoring and manipulation
Quantification of voluntary behaviours
Fast-scan cyclic voltammetry