Evoked resonant neural activity in subthalamic local field potentials reflects basal ganglia network dynamics.

Wiest C
He S
Duchet B
Pogosyan A
Benjaber M
Denison T
Hasegawa H
Ashkan K
Baig F
Bertaina I
Morgante F
Pereira EA
Torrecillos F
Tan H

Here, we study a brain signal that is evoked by electrical stimulation in Parkinson’s. We show how this signal changes with Parkinson’s medication, different stimulation intensities and frequencies and different modes of stimulation. Our results suggest that this signal may be useful for optimising stimulation parameters and better stimulation control.

Scientific Abstract

Evoked resonant neural activity (ERNA) is induced by subthalamic deep brain stimulation (DBS) and was recently suggested as a marker of lead placement and contact selection in Parkinson's disease. Yet, its underlying mechanisms and how it is modulated by stimulation parameters are unclear. Here, we recorded local field potentials from 27 Parkinson's disease patients, while leads were externalised to scrutinise the ERNA. First, we show that ERNA in the time series waveform and spectrogram likely represent the same activity, which was contested before. Second, our results show that the ERNA has fast and slow dynamics during stimulation, consistent with the synaptic failure hypothesis. Third, we show that ERNA parameters are modulated by different DBS frequencies, intensities, medication states and stimulation modes (continuous DBS vs. adaptive DBS). These results suggest the ERNA might prove useful as a predictor of the best DBS frequency and lowest effective intensity in addition to contact selection. Changes with levodopa and DBS mode suggest that the ERNA may indicate the state of the cortico-basal ganglia circuit making it a putative biomarker to track clinical state in adaptive DBS.

Two plots of DBS frequencies and DBS currents
ERNA amplitudes and latencies differ with increasing DBS frequencies (A) and increasing DBS intensities (B)

2023. Neurobiol Dis, 178:106019.

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