Jacob joined the Stagg Group for his D.Phil. studies following his role as a Junior Researcher and Laboratory Manager at the Oxford Cognitive Neuropsychological Centre, located within the Department of Experimental Psychology at the University of Oxford. Jacob conducted his M.Sc. in Experimental Psychology at the University of Oxford, and previously spent two years as a Research Technician & Clinical Research Coordinator at Massachusetts General Hospital, Harvard Medical School, USA. His undergraduate degree was in Cognitive Studies (Endicott College, USA).
For his D.Phil. research, Jacob has been awarded a National Institutes of Health Oxford-Cambridge Scholars Fellowship. Part of Jacob’s D.Phil. work focuses on quantifying the dynamic aspects of neurochemicals using functional magnetic resonance spectroscopy (fMRS), an in vivo imaging technique that can be used to measure task-relevant modulation of neurochemicals in the human brain. By acquiring blood-oxygen level-dependent (BOLD) contrast images alongside fMRS measures, Jacob is working towards a new understanding of how these two different physical scales of brain function are correlated with one another, as well as investigating how brain imaging metrics from these sequences can be used as markers of subject-specific motor learning abilities. In addition to using these methods in the motor system of healthy participants, Jacob also works with clinical imaging data from people affected by stroke. Specifically, he works on lesion symptom mapping techniques with a view to characterising how stroke affected brain tissue results in behavioural deficits and recovery. Jacob conducts this research under the co-supervision of Prof Charlotte Stagg, Dr Nele Demeyere (University of Oxford) and Dr. Peter Bandettini (National Institutes of Health, USA).