Dr. Tommas Ellender

ellender

Dr. Tommas Ellender

MRC Career Development Fellow

Dr. Tommas Ellender completed his D.Phil. in Integrative Physiology at the University of Oxford in 2009 under the supervision of Professor Ole Paulsen. He was then recruited as a postdoctoral fellow to work with Professor Paul Bolam in Oxford, during which Tommas became fascinated by the complex circuitry of the basal ganglia. In 2010, Tommas was elected as a Biomedical Junior Research Fellow at Linacre College, Oxford. In 2012, he moved to the Department of Pharmacology to undertake postdoctoral work with Colin Akerman, where his research was focused on the developmental processes underlying the construction of neural circuits. He concurrently held a Research Associate position at Corpus Christi College, Oxford.

In 2015, Tommas was awarded a MRC Career Development Award, enabling him to pursue an independent research programme at the Department of Pharmacology. His current research is focused on defining the early developmental processes controlling the formation of the striatum, with the aim of generating rationale and identifying targets for intervention in a range of neurodevelopmental disorders involving the basal ganglia.

Key Research Areas
  • Development of the neuronal circuits of the striatum.
  • Neuromodulation of striatal circuit function.
  • Cellular mechanisms underlying the generation of physiological and pathological neuronal network activity.
Research Techniques
  • In vitro multi-neuron patch-clamp electrophysiology.
  • In vivo neonatal multi-channel extracellular recording.
  • Optogenetic and pharmacogenetic manipulation of neuronal activity.
  • Quantitative anatomical methods and single-neuron reconstruction.
Optogenetic study of thalamostriatal pathways.

Optogenetic study of thalamostriatal pathways.

Confocal image stack of two striatal medium-sized densely-spiny neurons labelled with streptavidin-Cy3 (in red). The two spiny neurons are embedded in a network of GFP-labelled D1 receptor-expressing spiny neurons (in green).

Confocal image stack of two striatal medium-sized densely-spiny neurons labelled with streptavidin-Cy3 (in red). The two spiny neurons are embedded in a network of GFP-labelled D1 receptor-expressing spiny neurons (in green).

Recent Publications

Smith Y
Galvan A
Ellender TJ
Doig NM
Villalba RM
Huerta-Ocampo I
Wichmann T
Bolam JP

2014.Front Syst Neurosci, 8():5.

Ellender TJ
Raimondo JV
Irkle A
Lamsa KP
Akerman CJ
2014.J. Neurosci., 34(46):15208-22.
Ellender TJ
Harwood J
Kosillo P
Capogna M
Bolam JP

2013.J. Physiol. (Lond.), 591(1):257-72.

Raimondo JV
Kay L
Ellender TJ
Akerman CJ

2012.Nat. Neurosci., 15(8):1102-4.

Ellender TJ
Huerta-Ocampo I
Deisseroth K
Capogna M
Bolam JP
2011.J. Neurosci., 31(43):15340-51.